Association of TCF4 polymorphisms and fuchs’ endothelial dystrophy: a meta-analysis
نویسندگان
چکیده
منابع مشابه
Association of TCF4 polymorphisms and fuchs’ endothelial dystrophy: a meta-analysis
BACKGROUND Studies investigating the associations between transcription factor 4 (TCF4) genetic polymorphisms and Fuchs' endothelial dystrophy (FED) have reported controversial results. Therefore, this meta-analysis aims to clarify the effects of TCF4 polymorphisms on FED risk. METHODS A meta-analysis was conducted to assess the association between four single nucleotide polymorphisms (SNPs) ...
متن کاملAssociation of TCF4 gene polymorphisms with Fuchs' corneal dystrophy in the Chinese.
PURPOSE To test the association between TCF4, a gene recently found to confer susceptibility to Fuchs' corneal dystrophy (FCD) in Caucasian populations, and Chinese patients with FCD. METHODS Fifty-seven Chinese subjects with clinically diagnosed FCD and 121 normal control subjects were recruited. Genomic DNA was extracted and the 18 single nucleotide polymorphisms (SNPs) within TCF4 were gen...
متن کاملReplication of TCF4 through Association and Linkage Studies in Late-Onset Fuchs Endothelial Corneal Dystrophy
Fuchs endothelial corneal dystrophy (FECD) is a common, late-onset disorder of the corneal endothelium. Although progress has been made in understanding the genetic basis of FECD by studying large families in which the phenotype is transmitted in an autosomal dominant fashion, a recently reported genome-wide association study identified common alleles at a locus on chromosome 18 near TCF4 which...
متن کاملAssociation of polymorphisms in the intron of TCF4 gene to late-onset Fuchs endothelial corneal dystrophy: An Indian cohort study
PURPOSE Fuchs endothelial corneal dystrophy (FECD) is a progressive degenerative disease of the corneal endothelium. It is genetically heterogeneous and follows either an autosomal dominant or sporadic pattern of inheritance. Here, we have explored the association of four previously reported intronic single nucleotide polymorphisms and intronic CTG repeat expansions in TCF4 gene to FECD in an I...
متن کاملAssociation of Common Variants in TCF4 and PTPRG with Fuchs' Corneal Dystrophy: A Systematic Review and Meta-Analysis
TOPIC A meta-analysis of TCF4 and PTPRG gene variants in Fuchs' corneal dystrophy (FCD). CLINICAL RELEVANCE To identify novel genetic markers in patients with FCD in different ethnic populations. METHODS MEDLINE and EMBASE were searched for eligible genetic studies on TCF4 and PTPRG in FCD. Odds ratios (OR) and 95% confidence intervals (CI) of each single-nucleotide polymorphism (SNP) in al...
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ژورنال
عنوان ژورنال: BMC Ophthalmology
سال: 2015
ISSN: 1471-2415
DOI: 10.1186/s12886-015-0055-6